Experimental models for hepatitis C viral infection

Experimental models for hepatitis C virus (HCV): new opportunities for combating hepatitis C.

Infection with hepatitis C virus (HCV) is a global public health issue. More than 200 million people in the world are infected with HCV. Hepatitis C is considered one of the main causes of chronic hepatitis, cirrhosis, hepatocellular carcinoma and liver transplantation. The identification of the viral genome quickly allowed delineation of genomic organization, and the structure and biochemical ...

Experimental Viral Hepatitis

The use of improved fixation in glutaraldehyde and related materials, plastic embedding, ultra-thin sections, phase contrast optics for viewing, and the use of abundant electron micrographs, stereoscans and replicas have permitted a degree of visualization not before possible. Clearly, the beginning student will find in this book a way of introducing himself to the complex structure and develop...

Immunotactoid glomerulopathy in a patient with hepatitis C viral infection.

Viral sequence evolution in acute hepatitis C virus infection.

CD8(+)-T-cell responses play an important role in the containment and clearance of hepatitis C virus (HCV) infection, and an association between viral persistence and development of viral escape mutations has been postulated. While escape from CD8+ -T-cell responses has been identified as a major driving force for the evolution of human immunodeficiency virus (HIV) and simian immunodeficiency v...

Hepatitis C viral infection is not associated with Waldenström's macroglobulinemia.

While a familial predisposition may exist in up to 20% of patients with Waldenström's Macroglobulinemia (WM), the precipitating cause of this B-cell malignancy remains unknown in most patients. In previous studies, an association between hepatitis C virus (HCV) infection and WM has been suggested as etiological. This relationship has been the subject of debate, however, with some studies demons...